Third edition Silverman, Richard B. creator Holladay, Mark W. text xxu Amsterdam Academic Press, an imprint of Elsevier ©2014 monographic eng

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xviii, 517 pages : illustrations ; 24 cm. Abstract : Provides a basis and overall context for concepts introduced and discussed in more detail in subsequent chapters in this book. An historical context is given to the topic of drug discovery, followed by a high level overview of modern approaches to rational drug design. The approaches and steps typically encountered in modern rational drug design, including target identification, lead discovery, and lead modification, are introduced, and an overview of the subsequent steps required for drug development prior to regulatory approval, such as pharmacokinetics, preclinical studies, clinical trials, and intellectual property issues, are summarized. Chapter 1 - Introduction, In The Organic Chemistry of Drug Design and Drug Action Chapter 2 - Lead Discovery and Lead Modification, Chapter 3 - Receptors, In The Organic Chemistry of Drug Design and Drug Action Chapter 4 - Enzymes, In The Organic Chemistry of Drug Design and Drug Action Chapter 5 - Enzyme Inhibition and Inactivation, Chapter 6 - DNA-Interactive Agents, Chapter 7 - Drug Resistance and Drug Synergism, Chapter 8 - Drug Metabolism, Chapter 9 - Prodrugs and Drug Delivery Systems, Bioorganic chemistry Pharmaceutical chemistry Molecular pharmacology Drugs Design E-Books 615.1 SIL 9780123820303 Global Information Systems Technology Pvt Ltd 877, Udhyog Vihar, Phase-V, Gurgaon http://www.sciencedirect.com/science/book/9780123820303 http://www.sciencedirect.com/science/book/9780123820303 160413 20160926140407.0