TY  - BOOK
AU  - Silverman, Richard B.,
AU  - Holladay, Mark W.,
TI  - The organic chemistry of drug design and drug action: Third edition 
SN  - 9780123820303
U1  - 615.1 SIL 
PY  - 2014///
CY  - Amsterdam
PB  - Academic Press, an imprint of Elsevier
KW  - Bioorganic chemistry
KW  - Pharmaceutical chemistry
KW  - Molecular pharmacology
KW  - Drugs
KW  - Design
KW  - E-Books
N1  - Chapter 1 - Introduction, In The Organic Chemistry of Drug Design and Drug Action; http://www.sciencedirect.com/science/article/pii/B9780123820303000015; Chapter 2 - Lead Discovery and Lead Modification; http://www.sciencedirect.com/science/article/pii/B9780123820303000027; Chapter 3 - Receptors, In The Organic Chemistry of Drug Design and Drug Action; http://www.sciencedirect.com/science/article/pii/B9780123820303000039; Chapter 4 - Enzymes, In The Organic Chemistry of Drug Design and Drug Action; http://www.sciencedirect.com/science/article/pii/B9780123820303000040; Chapter 5 - Enzyme Inhibition and Inactivation,; http://www.sciencedirect.com/science/article/pii/B9780123820303000052; Chapter 6 - DNA-Interactive Agents; http://www.sciencedirect.com/science/article/pii/B9780123820303000064; Chapter 7 - Drug Resistance and Drug Synergism; http://www.sciencedirect.com/science/article/pii/B9780123820303000076; Chapter 8 - Drug Metabolism; http://www.sciencedirect.com/science/article/pii/B9780123820303000088; Chapter 9 - Prodrugs and Drug Delivery Systems; http://www.sciencedirect.com/science/article/pii/B978012382030300009X
N2  - Abstract : Provides a basis and overall context for concepts introduced and discussed in more detail in subsequent chapters in this book. An historical context is given to the topic of drug discovery, followed by a high level overview of modern approaches to rational drug design. The approaches and steps typically encountered in modern rational drug design, including target identification, lead discovery, and lead modification, are introduced, and an overview of the subsequent steps required for drug development prior to regulatory approval, such as pharmacokinetics, preclinical studies, clinical trials, and intellectual property issues, are summarized
UR  - http://www.sciencedirect.com/science/book/9780123820303
ER  -