TY - BOOK AU - Hamblin, Michael R AU - Hamblin, Michael R AU - Karimi, Mahdi TI - Biomedical Applications of Microfluidic Devices SN - 9780128187913 U1 - 610.284 HAM PY - 2021/// CY - Amsterdam PB - : Academic Press, KW - Technology KW - Medicine and health KW - Medical instruments and apparatus KW - Microfluidic devices KW - Microfluidics N1 - Intro -- Biomedical Applications of Microfluidic Devices -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Chapter 1 An overview of microfluidic devices -- 1.1 Introduction -- 1.2 Chemical synthesis -- 1.3 Drug delivery -- 1.4 Cell biology -- 1.5 Biosensors -- References -- Chapter 2 Microfluidic devices: Synthetic approaches -- 2 Cleanroom -- 2.1 Classification -- 2.2 Cleanroom concepts -- 2.3 Cleanroom equipment -- 2.4 Materials -- 2.4.1 Polydimethylsiloxane -- 2.4.2 SU-8 -- 2.4.3 Silicon -- 2.4.4 Glass -- 2.4.5 Nonmetal thin films -- 2.4.6 Metals 2.5 Deposition methods -- 2.5.1 Deposition methods for Si 3 N 4 and SiO 2 -- 2.5.2 Deposition methods for thin metal layers -- 2.5.3 Deposition methods for thick metal layers -- 2.6 Lithography -- 2.6.1 Photolithography -- 2.7 Etching techniques -- 2.7.1 Features of etching procedures -- 2.7.2 Wet etching of thin films -- 2.7.3 Isotropic wet etching of silicon and glass -- 2.7.4 Anisotropic wet etching of silicon -- 2.7.5 Dry etching methods -- 2.8 Types of molding -- 2.8.1 Soft lithography -- 2.8.2 Injection molding -- 2.8.3 Hot embossing -- 2.9 3D printing -- 2.10 Stereolithography 2.11 Fused deposition molding -- References -- Chapter 3 Microchannels for microfluidic systems -- 3.1 Introduction -- 3.2 Cross-section geometry in microchannels in microfluidic systems -- 3.3 Channel design for different flow regimes (turbulent and laminar flow) -- 3.4 Phase study in microfluidic devices and microchannel patterns -- 3.5 Hydrodynamic behavior of the flow in microfluidic systems -- 3.6 The velocity development in the microchannels -- 3.7 Hydrophilicity and hydrophobicity effects in microfluidic systems -- 3.8 Physical specifications of channels in microfluidic systems 3.8.1 Effect of friction coefficient of the microchannels in microfluidic devices -- 3.8.2 Roughness effects in channels of microfluidic devices -- 3.9 Biomedical applications of transport phenomena in microfluidic systems -- 3.10 Pathogen detection by microchannel devices using nanotechnology -- 3.11 Soft microchannels in biomedical applications -- 3.12 Reusable microchannels in biomedical applications -- 3.13 Conclusions -- References -- Chapter 4 Microarray technologies -- 4.1 Introduction -- 4.2 What are microarrays? -- 4.2.1 DNA microarrays -- 4.2.1.1 Fabrication methods for DNA microarrays 4.2.2 Protein microarrays -- 4.2.2.1 Analytical protein microarrays -- 4.2.2.2 Functional protein microarrays -- 4.2.2.3 Reverse phase microarrays -- 4.2.2.4 Fabrication of protein microarrays -- 4.2.3 Cell microarrays -- 4.3 Microfluidic arrays -- 4.3.1 Advantages of microfluidic array technology -- 4.3.2 Disadvantages of microfluidic array technology -- 4.3.3 Fabrication of microfluidic arrays -- 4.3.4 Automated microfluidic arrays (lab-on-a-chip systems) -- 4.3.5 Examples of microfluidic arrays -- 4.4 Conclusion -- References -- Chapter 5 Microfluidics: Organ-on-a-chip ER -