01636nam a22002057a 450000500170000000800410001702000180005802800830007608200150015910000150017424500900018926000370027930000220031636500090033852010190034765000130136665000240137965000130140370000140141620240402124355.0240215b        |||||||| |||| 00| 0 eng d  a9781032411859  a: Zafaa Books & Distributorsb: 313/56F, 49A, Anand Nagar, Inderlok, Delhic:   a610.72 ALO  aAlon, Uri.  aSystems Medicine.b: Physiological Circuits and the Dynamics of Disease.c/ Uri Alon.  a, New Yorkb: CRC Pressc, 2024.  axi,255p.c: 24cm.  b4234  aWhy do we get certain diseases, whereas other diseases do not exist?

In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine.

Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them.

By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases.

Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom.

  aMedicine  aDynamics of Disease  aBiology   aUri Alon.