Principles of protein structure /G E Schulz

By: G E Schulz ; R Heiner SchirmerContributor(s): R Heiner SchirmerMaterial type: TextTextPublisher number: Atlantic Publishers & Distributors (P) Ltd. | ;7/22,Ansari Road ,Darya Ganj,New Delhi-110002Series: Springer advanced texts in chemistryPublication details: New York : Springer-Verlag , ©1979Description: x, 314 pages ; 24 cmISBN: 9780387903347Subject(s): ProteinsGenre/Form: Macromolecular Substances.DDC classification: 547.75 SCH
Contents:
1 Amino Acids.- 1.1 The 20 Standard Amino Acids.- 1.2 Why Were Just These Amino Acids Selected?.- 1.3 Colinear Relation Between Nucleic Acids and Polypeptides.- 1.4 Side Chain Properties.- 1.5 Empirical Similarities Between Amino Acid Residues.- Summary.- 2 Structural Implications of the Peptide Bond.- 2.1 Synthesis on Ribosomes.- 2.2 Peptide Bond Dimensions.- 2.3 Steric Hindrance.- 2.4 Conformational Energy.- 2.5 cis versus trans Configuration.- Summary.- 3 Noncovalent Forces Determining Protein Structure.- 3.1 Dispersion Forces and Electron Shell Repulsion.- 3.2 Electrostatic Interactions.- 3.3 Van der Waals Potentials.- 3.4 Hydrogen Bonds.- 3.5 Entropic Forces.- 3.6 Molecular Packing.- Summary.- 4 The Covalent Structure of Proteins.- 4.1 Chain Assemblies.- 4.2 Disulfide Bonds.- 4.3 Enzyme-Controlled Modifications of the Main Chain.- 4.4 Enzyme-Controlled Side Chain Modifications.- Summary.- 5 Patterns of Folding and Association of Polypeptide Chains.- 5.1 Secondary Structure.- 5.2 Supersecondary Structures.- 5.3 Structural Domains.- 5.4 Globular Proteins.- 5.5 Aggregates of Globular Proteins.- 5.6 Hierarchy of Levels.- Summary.- 6 Prediction of Secondary Structure from the Amino Acid Sequence.- 6.1 Probabilistic Methods.- 6.2 Physico-Chemical Methods.- 6.3 Application of Prediction Methods.- 6.4 Evaluation of Prediction Methods.- 6.5 Emerging General Results.- Summary.- 7 Models, Display, and Documentation of Protein Structures.- 7.1 Structural Ingredients.- 7.2 Representations of Complete Structures.- 7.3 Abstract Chain Fold Representations.- Summary.- 8 Thermodynamics and Kinetics of Polypeptide Chain Folding.- 8.1 Thermodynamic Aspects.- 8.2 Speed, Precision, and Limitations of Folding in vitro.- 8.3 Structural Elements in Unfolded Chains.- 8.4 Folding Pathway.- 8.5 The Influence of Ligands.- 8.6 Simulations of the Folding Process.- Summary.- 9 Protein Evolution.- 9.1 Protein Speciation.- 9.2 Phylogeny on the Basis of Protein Structures.- 9.3 Protein Differentiation.- 9.4 Gene Fusion.- 9.5 Convergent Evolution in Proteins.- 9.6 Recognition of Distant Relationships.- Summary.- 10 Protein-Ligand Interactions.- 10.1 Ligand-Binding Sites of Immunoglobulins.- 10.2 Substrate-Binding Sites of Serine Proteases.- 10.3 Haem-Binding Sites.- 10.4 Nucleotide-Binding Sites.- 10.5 Binding Sites for Phosphoryl Groups.- 10.6 Interactions of Proteins With Other Macromolecules.- Summary.- 11 The Structural Basis of Protein Mechanism, Action, and Function.- 11.1 Definitions.- 11.2 Enzyme Catalysis.- 11.3 Biological and Medical Aspects of Protein Action and Function.- 11.4 Skeletal Muscle, a System in Which Protein Action Can be Related to the Overall Performance of an Organ.- Summary.- Appendix Statistical Mechanics of the Helix-Coil Transition.- A.1 Partition Function.- A.2 Probability of a Residue Being in a Certain Conformation.- A.3 Ising Model.- A.4 Zimm-Bragg Model for Helix-Coil Transition.- A.5 Comparision With Experimental Data.- References.
Summary: New textbooks at all levels of chemistry appear with great regularity. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.
List(s) this item appears in: opac_display
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Call number Status Date due Barcode Item holds
Books Books SNU LIBRARY
547.75 SCH (Browse shelf(Opens below)) Not For Loan 27190
Total holds: 0

1 Amino Acids.- 1.1 The 20 Standard Amino Acids.- 1.2 Why Were Just These Amino Acids Selected?.- 1.3 Colinear Relation Between Nucleic Acids and Polypeptides.- 1.4 Side Chain Properties.- 1.5 Empirical Similarities Between Amino Acid Residues.- Summary.- 2 Structural Implications of the Peptide Bond.- 2.1 Synthesis on Ribosomes.- 2.2 Peptide Bond Dimensions.- 2.3 Steric Hindrance.- 2.4 Conformational Energy.- 2.5 cis versus trans Configuration.- Summary.- 3 Noncovalent Forces Determining Protein Structure.- 3.1 Dispersion Forces and Electron Shell Repulsion.- 3.2 Electrostatic Interactions.- 3.3 Van der Waals Potentials.- 3.4 Hydrogen Bonds.- 3.5 Entropic Forces.- 3.6 Molecular Packing.- Summary.- 4 The Covalent Structure of Proteins.- 4.1 Chain Assemblies.- 4.2 Disulfide Bonds.- 4.3 Enzyme-Controlled Modifications of the Main Chain.- 4.4 Enzyme-Controlled Side Chain Modifications.- Summary.- 5 Patterns of Folding and Association of Polypeptide Chains.- 5.1 Secondary Structure.- 5.2 Supersecondary Structures.- 5.3 Structural Domains.- 5.4 Globular Proteins.- 5.5 Aggregates of Globular Proteins.- 5.6 Hierarchy of Levels.- Summary.- 6 Prediction of Secondary Structure from the Amino Acid Sequence.- 6.1 Probabilistic Methods.- 6.2 Physico-Chemical Methods.- 6.3 Application of Prediction Methods.- 6.4 Evaluation of Prediction Methods.- 6.5 Emerging General Results.- Summary.- 7 Models, Display, and Documentation of Protein Structures.- 7.1 Structural Ingredients.- 7.2 Representations of Complete Structures.- 7.3 Abstract Chain Fold Representations.- Summary.- 8 Thermodynamics and Kinetics of Polypeptide Chain Folding.- 8.1 Thermodynamic Aspects.- 8.2 Speed, Precision, and Limitations of Folding in vitro.- 8.3 Structural Elements in Unfolded Chains.- 8.4 Folding Pathway.- 8.5 The Influence of Ligands.- 8.6 Simulations of the Folding Process.- Summary.- 9 Protein Evolution.- 9.1 Protein Speciation.- 9.2 Phylogeny on the Basis of Protein Structures.- 9.3 Protein Differentiation.- 9.4 Gene Fusion.- 9.5 Convergent Evolution in Proteins.- 9.6 Recognition of Distant Relationships.- Summary.- 10 Protein-Ligand Interactions.- 10.1 Ligand-Binding Sites of Immunoglobulins.- 10.2 Substrate-Binding Sites of Serine Proteases.- 10.3 Haem-Binding Sites.- 10.4 Nucleotide-Binding Sites.- 10.5 Binding Sites for Phosphoryl Groups.- 10.6 Interactions of Proteins With Other Macromolecules.- Summary.- 11 The Structural Basis of Protein Mechanism, Action, and Function.- 11.1 Definitions.- 11.2 Enzyme Catalysis.- 11.3 Biological and Medical Aspects of Protein Action and Function.- 11.4 Skeletal Muscle, a System in Which Protein Action Can be Related to the Overall Performance of an Organ.- Summary.- Appendix Statistical Mechanics of the Helix-Coil Transition.- A.1 Partition Function.- A.2 Probability of a Residue Being in a Certain Conformation.- A.3 Ising Model.- A.4 Zimm-Bragg Model for Helix-Coil Transition.- A.5 Comparision With Experimental Data.- References.

New textbooks at all levels of chemistry appear with great regularity. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.

There are no comments on this title.

to post a comment.

© Copyright Shiv Nadar University 2012. All Rights Reserved.  Disclaimer |  Sitemap
The Shiv Nadar University has been established under U.P. Act No 12 of 2011. Shiv Nadar University is UGC Approved.