Medicinal Chemistry of Anticancer Drugs / Avendaño, Carmen.

Chapter 1 - General Aspects of Cancer Chemotherapy,

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Chapter 2 - Antimetabolites That Interfere with Nucleic Acid Biosynthesis,

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Chapter 3 - Anticancer Drugs That Modulate Hormone Action,

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Chapter 4 - Anticancer Drugs Acting via Radical Species: Radiotherapy and Photodynamic Therapy of Cancer,

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Chapter 5 - DNA Alkylating Agents,

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Chapter 6 - Anticancer Drugs That Interact with the DNA Minor Groove,

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Chapter 7 - Other Anticancer Drugs Targeting DNA and DNA-Associated Enzymes,

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Chapter 8 - Epigenetic Therapy of Cancer,

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Chapter 9 - Anticancer Drugs Targeting Tubulin and Microtubules,

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Chapter 10 - Drugs That Inhibit Signaling Pathways for Tumor Cell Growth and Proliferation: Kinase Inhibitors, Chapter 11 - Other Nonbiological Approaches to Targeted Cancer Chemotherapy,
Chapter 12 - Biological Therapy of Cancer,
Chapter 13 - Drug Targeting in Anticancer Chemotherapy,
Chapter 14 - Drugs That Modulate Resistance to Antitumor Agents,
Chapter 15 - Cancer Chemoprevention,

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Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.

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