Principles of asymmetric synthesis (Record no. 60109)

MARC details
000 -LEADER
fixed length control field 03640nam a22002657a 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20230403102204.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780080448602
028 ## - DISTRIBUTOR NAME
Distributor Name : Zafaa Books & Distributors
Distributor address : 313/56F,49A, Anand Nagar, Inderlok, Delhi.
Bill Number : ZBD0675
Bill Date : 24/03/2023
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547.2 GAW
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Gawley, Robert E.
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name ; Aube, Jeffrey
245 ## - TITLE STATEMENT
Title Principles of asymmetric synthesis
Statement of responsibility, etc / Robert E. Gawley.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc , Amsterdam
Name of publisher, distributor, etc : Elsevier
Date of publication, distribution, etc , 2012.
300 ## - PHYSICAL DESCRIPTION
Extent xii,555p.
Dimensions :24cm.
365 ## - TRADE PRICE
Price amount 5826
505 ## - FORMATTED CONTENTS NOTE
Contents note 1. Introduction, General Principles, and Glossary of Stereochemical Terms<br/>2. Practical Aspects of Asymmetric Synthesis<br/>3. Enolate, Azaenolate, and Organolithium Alkylations<br/>4. 1,2- and 1,4-Additions to C=X Bonds<br/>5. Aldol and Michael Additions of Allyls, Enolates, and Enolate Equivalents<br/>6. Cycloadditions and Rearrangements<br/>7. Reductions and Hydroborations<br/>8. Oxidations
520 ## - SUMMARY, ETC.
Summary, etc The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Asymmetric synthesis
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Asymmetrische Synthese
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Organic chemistry
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Chemistry Organic
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Robert E. Gawley.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Books
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Date acquired Source of acquisition Cost, normal purchase price Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification   Not For Loan SNU LIBRARY SNU LIBRARY 03/04/2023 Zafaa Books 5826.00 547.2 GAW 29177 03/04/2023 03/04/2023 Books
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