Intro; Preface; Contents; About the Editors; 1 A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics; Abstract; 1.1 Introduction; 1.2 Paper Microfluidics: Historical Perspective; 1.3 Outline; References; 2 Fluid Transport Mechanisms in Paper-Based Microfluidic Devices; Abstract; 2.1 Introduction; 2.2 Fluid Transport; 2.2.1 Classical Lucas-Washburn Equation (Capillary Flow); 2.2.2 Darcy's Law for Fluid Flow; 2.2.3 Fluid Transport in the Porous Media of Varying Cross Section/Arbitrary Shape; 2.2.4 Radial Fluid Transport in Porous Media 2.2.5 Diffusion-Based Fluid Transport2.2.6 Lateral Flow Immunoassay (LFIA); 2.3 Summary; References; 3 Fabrication Techniques for Paper-Based Microfluidic Devices; Abstract; 3.1 Introduction; 3.2 Fabrication Methods; 3.2.1 2D Fabrication Methods; 3.2.2 Flexographic Printing; 3.2.3 3D Fabrication Methods; 3.3 Comparison of Various Fabrication Methods; References; 4 Flow Control in Paper-Based Microfluidic Devices; Abstract; 4.1 Introduction; 4.2 Fluid Flow Through Porous Substrates; 4.2.1 Lucas-Washburn Equation; 4.2.2 Darcy's Equation for Fluid Flow 4.2.3 Richard's Equation for Partially Saturated Flows4.3 Controlling the Fluid Flow in Paperfluidic Devices; 4.3.1 Techniques to Achieve Flow Control Without Valves; 4.3.1.1 Changing the Channel Dimensions; 4.3.1.2 Creation of Alternate Flow Paths; 4.3.1.3 Changing the Surface Wettability; 4.3.1.4 Changing the Properties of the Porous Substrate; 4.3.1.5 Increasing the Resistance to Fluid Flow Using Physicochemical Barriers; 4.3.1.6 Electrostatic Interactions Between Device Components; 4.3.1.7 Varying the Channel Dimensions for Specific Introduction of Reagents 4.3.2 Techniques to Achieve Flow Control Utilizing Valve-Like Tools4.3.2.1 Dissolvable Species; 4.3.2.2 Mechanical Tools Which Connect or Disconnect Channels; 4.3.2.3 Wax-Based Valves; 4.3.2.4 Fluidic Diodes; 4.3.2.5 Automatically Actuated External Valves; 4.4 Challenges to Translation of Flow Control-Based Paperfluidic Devices; References; 5 Paper Microfluidic Based Device for Blood/Plasma Separation; Abstract; 5.1 Introduction; 5.2 Physiological Hemodynamics and Porous Media Hemodynamics; 5.3 Recent Advances in Paper Based Blood Plasma Separation Devices; 5.4 Summary and Future Perspectives

This volume provides an overview of the recent advances in the field of paper microfluidics, whose innumerable research domains have stimulated considerable efforts to the development of rapid, cost-effective and simplified point-of-care diagnostic systems. The book is divided into three parts viz. theoretical background of paper microfluidics, fabrication techniques for paper-based devices, and broad applications. Each chapter of the book is self-explanatory and focuses on a specific topic and its relation to paper microfluidics and starts with a brief description of the topics physical background, essential definitions, and a short story of the recent progress in the relevant field. The book also covers the future outlook, remaining challenges, and emerging opportunities. This book shall be a tremendous up-to-date resource for researchers working in the area globally